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After administration of PTER and RES at the same dose to male and female mice for 8 weeks, PTER reached higher concentrations in the serum and in the brain than RES ( The high lipophilicity of PTER allows it to easily cross the blood-brain barrier (Temsamani et al., 2015), resulting in greater neuroprotection than RES (Kutil et al., 2015), decreasing the levels of lipid and protein oxidation (Czpaski et al., 2012)

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That result is the single most informative datum in the entire AOD9604 record, because it is the direct test of the compound's founding hypothesis in the species of interest, and it is also the datum most reliably absent from promotional material